In a globalized economy where work is increasingly tenuous, the safety, health, and well-being of employees has become a matter of some urgency for organizational leaders, and an area of intense focus for researchers and practitioners. The Total Worker Health (R) program, an initiative of the National Institute for Occupational Safety and Health (NIOSH), targets policies, programs, and practices that address worker safety and health in both the physical and organizational work environment, as well as outside the workplace. Chapters in this book cover organizational approaches for program implementation, and offer examples of applications for diverse worker populations, including workers in health care settings, construction, corrections, and manufacturing; older adults who may have multiple chronic health conditions; low-wage workers; freelancers; and part-time workers. Contributors provide evidence of program effectiveness for addressing work conditions that impact mental health, fatigue and sleep, and work-life conflict. This volume is for occupational health professionals, human resource managers, policymakers, and organizational trailblazers who understand that building a culture of health is an essential best business practice.